![]() ![]() This pathology was traditionally related to a hypersecretory acid environment, dietary factors and stress. Peptic ulceration occurs due to acid peptic damage to the gastro-duodenal mucosa, resulting in mucosal erosion that exposes the underlying tissues to the digestive action of gastro-duodenal secretions. Peptic ulcer disease is common with a lifetime prevalence in the general population of 5-10% and an incidence of 0.1–0.3% per year. We divided our work into the two main topics, bleeding and perforated peptic ulcer, and structured it into six main topics that cover the entire management process of patients with complicated peptic ulcer, from diagnosis at ED arrival to post-discharge antimicrobial therapy, to provide an up-to-date, easy-to-use tool that can help physicians and surgeons during the decision-making process. ![]() These guidelines present evidence-based international consensus statements on the management of complicated peptic ulcer from a collaboration of a panel of experts and are intended to improve the knowledge and the awareness of physicians around the world on this specific topic. The population considered in these guidelines is adult patients with suspected complicated peptic ulcer disease. All the statements were presented and discussed during the 5th WSES Congress, and for each statement, a consensus among the WSES panel of experts was reached. To create these guidelines, a panel of experts was designed and charged by the board of the WSES to perform a systematic review of the available literature and to provide evidence-based statements with immediate practical application. The present guidelines have been developed according to the GRADE methodology. Successful management of patients with complicated peptic ulcer (CPU) involves prompt recognition, resuscitation when required, appropriate antibiotic therapy, and timely surgical/radiological treatment. ![]() Management may involve various subspecialties including surgeons, gastroenterologists, and radiologists. Peptic ulcer disease remains a significant healthcare problem, which can consume considerable financial resources. Despite a sharp reduction in incidence and rates of hospital admission and mortality over the past 30 years, complications are still encountered in 10–20% of these patients. Peptic ulcer disease is common with a lifetime prevalence in the general population of 5–10% and an incidence of 0.1–0.3% per year. ![]()
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